During the last few years, several new drugs have been introduced for treatment of. Effector gammadelta t cells and tumor cells as immune targets of. Prevention and management of adverse events of novel agents in. Pf528 rnaseq based risk stratification in multiple myeloma patients validates sky92 as a high risk marker in the commpass trial. Radiographic manifestations of multiple myeloma in the mandible. Clinical features and survival of multiple myeloma patients harboring.
Pdf insights on multiple myeloma treatment strategies. Faculty raymond alexanian houston, usa martine amiot nantes, france kenneth anderson boston, usa michel attal toulouse, france herve avetloiseau nantes, france. Haematologica is, therefore, epublishing pdf files of an early version of. Oggi riguarda, in tutta italia, 5 persone ogni 100 mila gli studi compiuti alle. Dimopoulos, 9 thierry facon, 10 catarina geraldes, 11 hartmut goldschmidt, 12 roman hajek, markus hansson, 14 krzysztof jamroziak, 15 merav leiba, 16 tamas masszi, 17 larisa mendeleeva. Highdose therapy has recently been shown to lead to a better outcome than standard treatment, mainly in younger patients. Mario boccadoro, divisione di ematologia delluniversita di torino. Sep 21, 2016 purpose there is a need for a simple, reliable staging system for multiple myeloma that can be applied internationally for patient classification and stratification. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment which is relatively insensitive.
Mieloma multiplo working party chairman mario boccadoro cochairman michele cavo antonio palumbo. Il quadro clinico denominato smouldering multiple myeloma. Monoclonal gammopathy of undetermined significance mgus and. The efficacy and safety of bortezomib and dexamethasone as a. Overt, symptomatic mm is characterized by the classic diagnostic triad. Risk of progression and survival in multiple myeloma. Mieloma amiloidosi practicechanaing u up ates with highlights from the 8 iwwm international workshop on waldenstroms disease and symposium on advances on multiple myelorna and. Mario boccadoro multiple myeloma mm typically afflicts elderly patients. Mieloma multiplo mario boccadoro, roberto mina ematologia. Patients had to be refractory to bortezomib administered either alone or in combination with other agents, defined as no response less than partial response while receiving therapy with a prior bortezomibcontaining regimens or progression on or. Crossref alastair smith, finn wisloff and diana samson, guidelines on the diagnosis and management of multiple myeloma 2005, british journal of. New surface antigens for the characterization of plasma cells in the era of novel agents vittorio emanuele muccio,1 elona saraci,1 milena gilestro,1 valter gattei,2 antonella zucchetto,2 monica astol. In italia spiega mario boccadoro, direttore della divisione di ematologia universitaria dellospedale molinette di torino le persone affette da mieloma multiplo sono 8.
Our monthly newsletter with a selection of the best posts. Giovanni battista, ospedale molinette, torino, italy tel. Interpretation of quality of life scores in multiple myeloma. Mieloma multiplo 15 stefania oliva, mario boccadoro introduzione ed epidemiologia il mieloma multiplo mm e una discrasia plasmacellulare maligna caratterizzata dalla proliferazione clonale di plasmacellule maligne nel midollo osseo e da accumulo di linfociti b e plasmacellule sintetizzanti immunoglobuline. The efficacy and safety of bortezomib and dexamethasone as a maintenance therapy in patients with advanced multiple myeloma who are responsive to salvage bortezomibcontaining regimens.
Mario boccadoro divisione universitaria di ematologia. Meletios dimopoulos, robert kyle, jeanpaul fermand, s. Munshi, sundar jagannath, on behalf of the international. Monoclonal gammopathy of undetermined significance mgus was identified in 3. Jul 29, 2011 promising new drugs are being evaluated for treatment of multiple myeloma mm, but their impact should be measured against the expected outcome in patients failing current therapies. Personalized therapy in multiple myeloma according to patient age. Eha 2018 multiple myeloma abstracts poster presentations on. The definition of smouldering multiple myeloma includes patients with at least 10% of monoclonal plasma cells in. Anderson, philippe moreau, seema singhal, hartmut goldschmidt, mario boccadoro. Gianluca gaidano, paola omede1, mario boccadoro1, sara. Patients and methods clinical and laboratory data were gathered on 10,750 previously untreated symptomatic myeloma patients from 17 institutions, including sites in north america, europe, and asia. Mario boccadoro alessandro pileri april 2224, 2004 torino centro congressi lingotto multiple myeloma 2004 2. Angelo corso faini, barbara castella, yuliya yakymiv, alberto l.
Preclinical studies showed that daratumumab may kill myeloma cells by complementmediated cytotoxicity, by antibodydependent cellular cytotoxicity, and by antibodydependent cellular. Jan 23, 2006 mario boccadoro, divisione di ematologia delluniversita di torino, azienda ospedaliera s. The reason for moving forward with testing of daratumumab for the treatment of multiple myeloma was the very high level of expression of cd38 by myeloma cells. Patients had to be refractory to bortezomib administered. Aug 09, 2018 palumbo a, bringhen s, caravita t, et al. Maintenance treatment and survival in patients with myeloma ncbi. Needless to say, june was a very active and productive month, reflecting the heart of our mission to bring together the myeloma community, and empower patients, doctors, nurses, and researchers with a common goal to find a cure. Apr 22, 2010 monoclonal gammopathy of undetermined significance mgus was identified in 3. Mariavictoria mateos, 1 heinz ludwig, 2 ali bazarbachi, 3 meral beksac, 4 joan blade, 5 mario boccadoro, 6 michele cavo, 7 michel delforge, 8 meletios a. Anderson, philippe moreau, seema singhal, hartmut goldschmidt, mario boccadoro, shaji kumar, sergio giralt, nikhil c. Needless to say, june was a very active and productive month, reflecting the heart of our mission to. Agestandardized incidence rate of mm from 1990 to 2016.
Most patients with newly diagnosed multiple myeloma mm are aged 65 years with. He also serves as coordinator of the postgraduate degree in. Lahuerta, heinz ludwig, gareth morgan, raymond powles, kazuyuki shimizu, chaim shustik, pieter sonneveld, patrizia tosi. Antonio palumbo, vittorio montefusco, gianluca gaidano, paola omede, mario boccadoro.
Mieloma amiloidosi practicechanaing u up ates with highlights from the 8 iwwm international workshop on waldenstroms disease and symposium on advances on multiple myelorna and amyloidosis held in london, lik august 17, napoli 1516 dicembre 2014 hotel excelsior. Horenstein, cristiano bracci, fabio morandi, alessandra larocca, stefania oliva, massimo massaia, mario boccadoro, fabio malavasi. Per proseguire occorre prestare il consenso al trattamento dei dati per tutte le finalita meglio descritte nellinformativa resa ex art. Intravenous melphalan, thalidomide and prednisone in.
Oncologia medica c, istituto nazionale tumori, milan. Frontiers daratumumab for the treatment of multiple myeloma. Mario boccadoro divisione universitaria di ematologia roma 1122015 mieloma multiplo. Multiple myeloma mm is a clonal plasma cell disorder whose prognosis is driven by the presence or. Vincent rajkumar, jesus san miguel, asher chanankhan, heinz ludwig, douglas joshua, jayesh mehta, morie gertz, herve avetloiseau, meral beksac, kenneth c. Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Pdf an analysis of which subgroups of multiple myeloma patients. Mieloma multiple, myeloma and lymphoma association of austria, and myeloma euronet romania. Mieloma multiplo paziente anziano copyright fse 2 superior efficacy with bortezomibplus melphalanprednisone vmp versus mp alone in previously untreated mm. Sie, sies, gitmo evidencebased guidelines on novel agents. Nuove strategie nella diagnosi e nella cura del mieloma. To analyze and compare the effectiveness of different maintenance. Consensus recommendations for standard investigative workup.
Monoclonal gammopathy of undetermined significance mgus. Epidemiologa nccn clinical practice guidelines in oncology. Promising new drugs are being evaluated for treatment of multiple myeloma mm, but their impact should be measured against the expected outcome in patients failing current therapies. Mieloma multiple anticuerpo especialidades medicas. Mariani s, muraro m, pantaleoni f, fiore f, nuschak b, peola s, foglietta m, palumbo a, coscia m, castella b, bruno b, bertieri r, boano l, boccadoro m, massaia m. Heinz ludwig, md,24 mario boccadoro, md,1 mariavictoria mateos, md. Benevolo g, larocca a, gentile m, pregno p, gay f, botto b, frairia c, evangelista a, morabito f, boccadoro m, vitolo u, palumbo a. Multiple myeloma incurable disease complete response. International myeloma working group consensus criteria for. Intravenous melphalan, thalidomide and prednisone in refractory. Vmcpvbap alternating combination chemotherapy is not superior to. Mariani s, muraro m, pantaleoni f, fiore f, nuschak b, peola s, foglietta m, palumbo a, coscia m, castella b, bruno b, bertieri r, boano l, boccadoro. Dr boccadoro has received honoraria from sanofi, celgene, amgen. Mario boccadoro to, fabrizio pane na gene profiling e mieloma multiplo.
Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma. Lahuerta, heinz ludwig, gareth morgan, raymond powles, kazuyuki shimizu, chaim shustik, pieter sonneveld, patrizia tosi, ingemar turesson, and jan westin abstract purpose there is a need for a simple, reliable staging system for multiple myeloma that can be applied. Multiple myeloma shows a wide range of tumorrelated. Apr 15, 2008 pdf link pdf citation antonio palumbo, thierry facon, pieter sonneveld, joan blade, massimo offidani, francesca gay, philippe moreau, anders waage, andrew spencer, heinz ludwig, mario boccadoro, jeanluc harousseau. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and. Mieloma multiplo working party chairman mario boccadoro cochairman. Pdf 3 years survival of patients with multiple myeloma. Maintenance treatment and survival in patients with myeloma. B in graftversushost disease and the efficacy of bortezomib in refractoryrelapsed mm through the inhibition. Purpose there is a need for a simple, reliable staging system for multiple myeloma that can be applied internationally for patient classification and stratification.
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